Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis.

ABSTRACT: Monozygotic or 'identical' twins have been widely studied to dissect the relative contributions of genetics and environment in human diseases. In multiple sclerosis (MS), an autoimmune demyelinating disease and common cause of neurodegeneration and disability in young adults, disease discordance in monozygotic twins has been interpreted to indicate environmental importance in its pathogenesis. However, genetic and epigenetic differences between monozygotic twins have been described, challenging the accepted experimental model in disambiguating the effects of nature and nurture. Here we report the genome sequences of one MS-discordant monozygotic twin pair, and messenger RNA transcriptome and epigenome sequences of CD4(+) lymphocytes from three MS-discordant, monozygotic twin pairs. No repr

SUBMITTER: Baranzini SE 

PROVIDER: S-EPMC2862593 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature