Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study.

ABSTRACT: Statins are commonly used for reducing cardiovascular disease risk but therapeutic benefit and reductions in levels of low-density lipoprotein cholesterol (LDL-C) vary among individuals. Other effects, including reductions in C-reactive protein (CRP), also contribute to treatment response. Metabolomics provides powerful tools to map pathways implicated in variation in response to statin treatment. This could lead to mechanistic hypotheses that provide insight into the underlying basis for individual variation in drug response. Using a targeted lipidomics platform, we defined lipid changes in blood samples from the upper and lower tails of the LDL-C response distribution in the Cholesterol and Pharmacogenetics study. Metabolic changes in responders are more comprehensive than those seen in

SUBMITTER: Kaddurah-Daouk R 

PROVIDER: S-EPMC2862962 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature