Detection of gene orthology from gene co-expression and protein interaction networks.

ABSTRACT:

Background

Ortholog detection methods present a powerful approach for finding genes that participate in similar biological processes across different organisms, extending our understanding of interactions between genes across different pathways, and understanding the evolution of gene families.

Results

We exploit features derived from the alignment of protein-protein interaction networks and gene-coexpression networks to reconstruct KEGG orthologs for Drosophila melanogaster, Saccharomyces cerevisiae, Mus musculus and Homo sapiens protein-protein interaction networks extracted from the DIP repository and Mus musculus and Homo sapiens and Sus scrofa gene coexpression networks extracted from NCBI's Gene Expression Omnibus using the decision tree, Naive-Bayes and Support Vector

SUBMITTER: Towfic F 

PROVIDER: S-EPMC2863066 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature