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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony.

ABSTRACT: The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2. Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct substrates, and unique cellular functions distinguish the complexes. Here, we review recent progress in our understanding of the regulation and function of mTOR signaling networks in cellular physiology.

SUBMITTER: Foster KG 

PROVIDER: S-EPMC2863215 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony.

Foster Kathryn G KG   Fingar Diane C DC  

The Journal of biological chemistry 20100315 19

The mammalian target of rapamycin (mTOR) protein kinase responds to diverse environmental cues to control a plethora of cellular processes. mTOR forms the catalytic core of at least two distinct signaling complexes known as mTOR complexes 1 and 2. Differing sensitivities to the mTOR inhibitor rapamycin, unique partner proteins, distinct substrates, and unique cellular functions distinguish the complexes. Here, we review recent progress in our understanding of the regulation and function of mTOR  ...[more]

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