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Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.

ABSTRACT: Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility.

SUBMITTER: Sugi T 

PROVIDER: S-EPMC2863409 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.

Sugi Tatsuki T   Kato Kentaro K   Kobayashi Kyosuke K   Watanabe Shumpei S   Kurokawa Hitomi H   Gong Haiyan H   Pandey Kishor K   Takemae Hitoshi H   Akashi Hiroomi H  

Eukaryotic cell 20100219 4

Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility. ...[more]

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