Human picobirnaviruses identified by molecular screening of diarrhea samples.

ABSTRACT: The global threat of (re)emerging infectious viruses requires a more effective approach regarding virus surveillance and diagnostic assays, as current diagnostics are often virus species specific and not able to detect highly divergent or unknown viruses. A systematic exploration of viruses that infect humans is the key to effectively counter the potential public health threat caused by new and emerging infectious diseases. The human gut is a known reservoir of a wide variety of microorganisms, including viruses. In this study, Dutch clinical diarrhea samples for which no etiological agent could be identified by available cell culture, serological, or nucleic acid-based tests were gathered. Large-scale molecular RNA virus screening based on host nucleic acid depletion, sequence-independent

SUBMITTER: van Leeuwen M 

PROVIDER: S-EPMC2863890 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature