A randomized trial of therapies for type 2 diabetes and coronary artery disease.

ABSTRACT:

Background

Optimal treatment for patients with both type 2 diabetes mellitus and stable ischemic heart disease has not been established.

Methods

We randomly assigned 2368 patients with both type 2 diabetes and heart disease to undergo either prompt revascularization with intensive medical therapy or intensive medical therapy alone and to undergo either insulin-sensitization or insulin-provision therapy. Primary end points were the rate of death and a composite of death, myocardial infarction, or stroke (major cardiovascular events). Randomization was stratified according to the choice of percutaneous coronary intervention (PCI) or coronary-artery bypass grafting (CABG) as the more appropriate intervention.

Results

At 5 years, rates of survival did not differ significa

SUBMITTER: BARI 2D Study Group 

PROVIDER: S-EPMC2863990 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature