Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.

ABSTRACT: The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

SUBMITTER: Malakhova M 

PROVIDER: S-EPMC2864125 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature