Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest).

ABSTRACT:

Background

FibroTest and elastography have been validated as biomarkers of liver fibrosis in the most frequent chronic liver diseases and in the fibrosis screening of patients with diabetes. One challenge was to use them for estimating the prevalence of fibrosis, identifying independent risk factors and to propose screening strategies in the general population.

Methods

We prospectively studied 7,463 consecutive subjects aged 40 years or older. Subjects with presumed advanced fibrosis (FibroTest greater than 0.48) were re-investigated in a tertiary center.

Results

The sample characteristics were similar to those of the French population. FibroTest was interpretable in 99.6%. The prevalence of presumed fibrosis was 2.8%, (209/7,463), including cirrhosis in 0.3% (25/7,46

SUBMITTER: Poynard T 

PROVIDER: S-EPMC2864202 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature