Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy.

ABSTRACT: In recent years, tyrosine kinases (TKs) have been recognized as central players and regulators of cancer cell proliferation, apoptosis, and angiogenesis, and are therefore considered suitable potential targets for anti-cancer therapies. Several strategies for targeting TKs have been developed, the most successful being monoclonal antibodies and small molecule tyrosine kinase inhibitors. However, increasing evidence of acquired resistance to these drugs has been documented, and extensive preclinical studies are ongoing to try to understand the molecular mechanisms by which cancer cells are able to bypass their inhibitory activity.This review intends to present the most recently identified molecular mechanisms that mediate acquired resistance to tyrosine kinase inhibitors, identified through

SUBMITTER: Sierra JR 

PROVIDER: S-EPMC2864216 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature