MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2.

ABSTRACT:

Background

Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-stream MYCN targets is miR-184, which is either directly or indirectly repressed by this transcription factor, possibly due to its pro-apoptotic effects when ectopically over-expressed in neuroblastoma cells. The purpose of this study was to elucidate the molecular mechanism by which miR-184 conveys pro-apoptotic effects.

Results

We demonstrate that the knock-down of endogenous miR-184 has the opposite effect of ectopic up-regulation, leading to enhanced neuroblastoma cell numbers. As a mechanism of how miR-184 causes apoptosis when over-expressed, and increa

SUBMITTER: Foley NH 

PROVIDER: S-EPMC2864218 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature