Changes in the vaginal microenvironment with metronidazole treatment for bacterial vaginosis in early pregnancy.

ABSTRACT:

Objective

Bacterial vaginosis (BV) is associated with preterm delivery, but there is little evidence that treatment improves pregnancy outcomes. We examined whether oral or vaginal metronidazole treatment for BV in early pregnancy was more effective in restoring the normal vaginal environment.

Methods

This was a randomized controlled trial comparing oral and intravaginal metronidazole for treatment of BV in early pregnancy (<20 weeks). Vaginal samples collected at baseline and 4 weeks after treatment were evaluated using gram stain, culture, colorimetric detection of sialidase, and immunoassay for measurement of proinflammatory cytokines interleukins-1beta, -6, -8 (IL-1beta, IL-6, IL-8) and secretory leukocyte protease inhibitor (SLPI). We compared the effect of treatment be

SUBMITTER: Mitchell C 

PROVIDER: S-EPMC2864467 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature