TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.

ABSTRACT: Replicative senescence forms a major barrier to tumor progression. Cancer cells bypass this by using one of the two known telomere maintenance mechanisms: telomerase or the recombination-based alternative lengthening of telomeres (ALT) mechanism. The molecular details of ALT are currently poorly understood. We have previously shown that telomerase is actively repressed through complex networks of kinase, gene expression, and chromatin regulation. In this study, we aimed to gain further understanding of the role of kinases in the regulation of telomerase expression in ALT cells. Using a whole human kinome small interfering RNA (siRNA) screen, we highlighted 106 kinases whose expression is linked to human telomerase reverse transcriptase (hTERT) promoter activity. Network modeling of transcr

SUBMITTER: Lafferty-Whyte K 

PROVIDER: S-EPMC2864478 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature