MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells.

ABSTRACT:

Background

Cells of the oligodendrocyte (OL) lineage play a vital role in the production and maintenance of myelin, a multilamellar membrane which allows for saltatory conduction along axons. These cells may provide immense therapeutic potential for lost sensory and motor function in demyelinating conditions, such as spinal cord injury, multiple sclerosis, and transverse myelitis. However, the molecular mechanisms controlling OL differentiation are largely unknown. MicroRNAs (miRNAs) are considered the "micromanagers" of gene expression with suggestive roles in cellular differentiation and maintenance. Although unique patterns of miRNA expression in various cell lineages have been characterized, this is the first report documenting their expression during oligodendrocyte maturation

SUBMITTER: Letzen BS 

PROVIDER: S-EPMC2864763 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature