Gene x environment interactions for ADHD: synergistic effect of 5HTTLPR genotype and youth appraisals of inter-parental conflict.

ABSTRACT:

Background

Serotonin genes have been hypothesized to play a role in the etiology of attention-deficit hyperactivity disorder (ADHD); prior work suggests that serotonin may interact with psychosocial stressors in ADHD, perhaps via mechanisms involved in emotional dysregulation. Because the development of behavioral and emotional regulation depends heavily both on the child's experience within the family context and the child's construals of that experience, children's appraisals of inter-parental conflict are a compelling candidate potentiator of the effects of variation within the serotonin transporter gene promoter polymorphism (5HTTLPR) on liability for ADHD.

Method

304 youth from the local community underwent a multi-informant diagnostic assessment procedure to identify A

SUBMITTER: Nikolas M 

PROVIDER: S-EPMC2865439 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature