Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes.

ABSTRACT: Genome-wide association studies (GWAS) have demonstrated the ability to identify the strongest causal common variants in complex human diseases. However, to date, the massive data generated from GWAS have not been maximally explored to identify true associations that fail to meet the stringent level of association required to achieve genome-wide significance. Genetics of gene expression (GGE) studies have shown promise towards identifying DNA variations associated with disease and providing a path to functionally characterize findings from GWAS. Here, we present the first empiric study to systematically characterize the set of single nucleotide polymorphisms associated with expression (eSNPs) in liver, subcutaneous fat, and omental fat tissues, demonstrating these eSNPs are significantly m

SUBMITTER: Zhong H 

PROVIDER: S-EPMC2865508 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature