A visual migraine aura locus maps to 9q21-q22.

ABSTRACT:

Objective

To identify susceptibility loci for visual migraine aura in migraine families primarily affected with scintillating scotoma type of aura.

Methods

We included Finnish migraine families with at least 2 affected family members with scintillating scotoma as defined by the International Criteria for Headache Disorders-II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have scintillating scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers.

Results

A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mappi

SUBMITTER: Tikka-Kleemola P 

PROVIDER: S-EPMC2865729 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature