Quality assessment of protein model-structures using evolutionary conservation.

ABSTRACT:

Motivation

Programs that evaluate the quality of a protein structural model are important both for validating the structure determination procedure and for guiding the model-building process. Such programs are based on properties of native structures that are generally not expected for faulty models. One such property, which is rarely used for automatic structure quality assessment, is the tendency for conserved residues to be located at the structural core and for variable residues to be located at the surface.

Results

We present ConQuass, a novel quality assessment program based on the consistency between the model structure and the protein's conservation pattern. We show that it can identify problematic structural models, and that the scores it assigns to the server model

SUBMITTER: Kalman M 

PROVIDER: S-EPMC2865859 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature