Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2.

ABSTRACT:

Background

Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7)).

Methods

In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry.

Results

The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P=7.79x10(-11)

SUBMITTER: Prokunina-Olsson L 

PROVIDER: S-EPMC2866032 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature