Molecular analysis of tumor margins by MALDI mass spectrometry in renal carcinoma.

ABSTRACT: The rate of tumor recurrence post resection suggests that there are underlying molecular changes in nearby histologically normal tissue that go undetected by conventional diagnostic methods that utilize contrast agents and immunohistochemistry. MALDI MS is a molecular technology that has the specificity and sensitivity to monitor and identify molecular species indicative of these changes. The current study utilizes this technology to assess molecular distributions within a tumor and adjacent normal tissue in clear cell renal cell carcinoma biopsies. Results indicate that the histologically normal tissue adjacent to the tumor expresses many of the molecular characteristics of the tumor. Proteins of the mitochondrial electron transport system are examples of such distributions. This work dem

SUBMITTER: Oppenheimer SR 

PROVIDER: S-EPMC2866033 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature