The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos.

ABSTRACT:

Background

Leukotrienes play an important role in allergic and inflammatory diseases, but reports on the involvement of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and leukotriene A(4) hydrolase (LTA4H) in asthma have been inconclusive.

Objective

To determine whether polymorphisms in ALOX5AP and LTA4H genes are risk factors for asthma in two different Latino groups: Mexicans and Puerto Ricans.

Methods

The LTA4H gene was sequenced in individuals from both groups to identify novel polymorphisms. Single-nucleotide polymorphisms (SNPs) in the ALOX5AP and LTA4H genes were analysed for associations with asthma and asthma-related phenotypes in 687 parent-child trios of Mexican and Puerto Rican origin.

Results

In LTA4H, five previously unknown polymorphism

SUBMITTER: Via M 

PROVIDER: S-EPMC2866051 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature