Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women.

ABSTRACT:

Background

The rs3803662 single nucleotide polymorphism (SNP) in the TOX3/LOC643714 region was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry and has been replicated in other populations of European ancestry. The position of the causal variant tagged by the rs3803662 marker is still unknown. In fact, because the rs3803662 polymorphism is located between the TOX3 and the LOC643714 loci, it is unclear which gene is the one causally related to the risk of breast cancer. Because linkage disequilibrium blocks are smaller in populations of African ancestry, fine-mapping in African ancestry samples might be an effective approach to narrowing the position of the causal variant(s) in the TOX3/LOC643714 loc

SUBMITTER: Ruiz-Narvaez EA 

PROVIDER: S-EPMC2866101 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature