The IC3D classification of the corneal dystrophies.

ABSTRACT:

Background

The recent availability of genetic analyses has demonstrated the shortcomings of the current phenotypic method of corneal dystrophy classification. Abnormalities in different genes can cause a single phenotype, whereas different defects in a single gene can cause different phenotypes. Some disorders termed corneal dystrophies do not appear to have a genetic basis.

Purpose

The purpose of this study was to develop a new classification system for corneal dystrophies, integrating up-to-date information on phenotypic description, pathologic examination, and genetic analysis.

Methods

The International Committee for Classification of Corneal Dystrophies (IC3D) was created to devise a current and accurate nomenclature.

Results

This anatomic classification co

SUBMITTER: Weiss JS 

PROVIDER: S-EPMC2866169 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature