Ontology highlight
ABSTRACT:
SUBMITTER: Marcotte DJ
PROVIDER: S-EPMC2866269 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20100301 3
Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, plays a crucial role in B-cell maturation and mast cell activation. Although the structures of the unphosphorylated mouse BTK kinase domain and the unphosphorylated and phosphorylated kinase domains of human ITK are known, understanding the kinase selectivity profiles of BTK inhibitors has been hampered by the lack of availability of a high resolution, ligand-bound BTK structure. Here, we report the crystal structures of the ...[more]