Comprehensive modeling and functional analysis of Toll-like receptor ligand-recognition domains.

ABSTRACT: Toll-like receptors (TLRs) are innate immune pattern-recognition receptors endowed with the capacity to detect microbial pathogens based on pathogen-associated molecular patterns. The understanding of the molecular principles of ligand recognition by TLRs has been greatly accelerated by recent structural information, in particular the crystal structures of leucine-rich repeat-containing ectodomains of TLR2, 3, and 4 in complex with their cognate ligands. Unfortunately, for other family members such as TLR7, 8, and 9, no experimental structural information is currently available. Methods such as X-ray crystallography or nuclear magnetic resonance are not applicable to all proteins. Homology modeling in combination with molecular dynamics may provide a straightforward yet powerful alternativ

SUBMITTER: Kubarenko AV 

PROVIDER: S-EPMC2866280 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature