Mechano-electric feedback in the fish heart.

ABSTRACT:

Background

Mechanoelectric feedback (MEF) describes the modulation of electrical activity by mechanical activity. This may occur via the activation of mechanosensitive ion channels (MSCs). MEF has not previously been investigated in fish ventricular tissue even though fish can greatly increase ventricular end diastolic volume during exercise which should therefore provide a powerful mechanical stimulus for MEF.

Methodology/principal finding

When the ventricles of extrinsically paced, isolated working trout hearts were dilated by increasing afterload, monophasic action potential (MAP) duration was significantly shortened at 25% repolarisation, unaltered at 50% repolarisation and significantly lengthened at 90% repolarisation. This observation is consistent with the activation

SUBMITTER: Patrick SM 

PROVIDER: S-EPMC2866336 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature