Synchronized changes to relative neuron populations in postnatal human neocortical development.

ABSTRACT:

Unlabelled

Mammalian prenatal neocortical development is dominated by the synchronized formation of the laminae and migration of neurons. Postnatal development likewise contains "sensitive periods" during which functions such as ocular dominance emerge. Here we introduce a novel neuroinformatics approach to identify and study these periods of active development. Although many aspects of the approach can be used in other studies, some specific techniques were chosen because of a legacy dataset of human histological data (Conel in The postnatal development of the human cerebral cortex, vol 1-8. Harvard University Press, Cambridge, 1939-1967). Our method calculates normalized change vectors from the raw histological data, and then employs k-means cluster analysis of the change vectors

SUBMITTER: Cooper DL 

PROVIDER: S-EPMC2866365 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature