Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?

ABSTRACT:

Objective

We sought to determine allele frequencies of 3 LAMC1 single nucleotide polymorphisms (SNPs) in Caucasian and African American (AA) women with stage>II pelvic organ prolapse (POP) (cases) and in ethnicity-matched controls with stageStudy designAllelic discrimination was performed for LAMC1 SNPs rs10911193 (C/T), rs20563 (A/G), and rs20558 (T/C). SNP and haplotype-specific tests were used to examine associations among POP, ethnicity, and LAMC1.

Results

In all, 411 women were enrolled. Significant differences in allele and haplotype frequencies existed among AAs and Caucasians: rs10911193 "T" (P=.0014); rs20563 "G" (P<.0001); rs20558 "C" (P<.0001); rs20563, rs20558 "GC"

SUBMITTER: Chen C 

PROVIDER: S-EPMC2866811 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature