Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.

ABSTRACT:

Background

Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.

Methods

We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease. We compared disease risk for genetically-raised triglyceride concentration (20,842 patients with coronary heart disease, 35,206 controls) with that recorded for equivalent differences in circulating triglyceride concentration in prospective studies (302 430 participants with no history of cardiovascular disease; 12,785 incident cases of coronary hear

SUBMITTER: Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration 

PROVIDER: S-EPMC2867029 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature