Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.

ABSTRACT: Dendritic epidermal T cells (DETC) express an invariant Vgamma3/Vdelta1 T-cell receptor, appear in fetal epidermis, and form a population of resident epidermal T cells. Their temporal development in the thymus has been studied extensively. However, little is known about the mechanisms involved in the embryonic trafficking of DETC from thymus to epidermis. We demonstrate that DETC in adult skin, as well as the DETC precursors in fetal thymus, express E and P selectin ligands (E- and P-lig). Mice deficient in alpha1,3 fucosyltransferases IV and VII (FTIV/VII) cannot synthesize the carbohydrate motifs that form key elements of these selectin ligands. The numbers of DETC in the epidermis of FTIV/VII(-/-) mice were dramatically reduced compared with normal mice. However, the development of DETC

SUBMITTER: Jiang X 

PROVIDER: S-EPMC2867765 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature