A novel family of cyst proteins with epidermal growth factor repeats in Giardia lamblia.

ABSTRACT:

Background

Giardia lamblia parasitizes the human small intestine to cause diarrhea and malabsorption. It undergoes differentiation from a pathogenic trophozoite form into a resistant walled cyst form. Few cyst proteins have been identified to date, including three cyst wall proteins (CWPs) and one High Cysteine Non-variant Cyst protein (HCNCp). They are highly expressed during encystation and are mainly targeted to the cyst wall.

Methodology and principal findings

To identify new cyst wall proteins, we searched the G. lamblia genome data base with the sequence of the Cryptosporidium parvum oocyst wall protein as a query and found an Epidermal Growth Factor (EGF)-like Cyst Protein (EGFCP1). Sequence analysis revealed that the EGF-like repeats of the EGFCP1 are similar to thos

SUBMITTER: Chiu PW 

PROVIDER: S-EPMC2867935 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature