Gene expression profiles help identify the tissue of origin for metastatic brain cancers.

ABSTRACT:

Background

Metastatic brain cancers are the most common intracranial tumor and occur in about 15% of all cancer patients. In up to 10% of these patients, the primary tumor tissue remains unknown, even after a time consuming and costly workup. The Pathwork Tissue of Origin Test (Pathwork Diagnostics, Redwood City, CA, USA) is a gene expression test to aid in the diagnosis of metastatic, poorly differentiated and undifferentiated tumors. It measures the expression pattern of 1,550 genes in these tumors and compares it to the expression pattern of a panel of 15 known tumor types. The purpose of this study was to evaluate the performance of the Tissue of Origin Test in the diagnosis of primary sites for metastatic brain cancer patients.

Methods

Fifteen fresh-frozen metastatic br

SUBMITTER: Wu AH 

PROVIDER: S-EPMC2867958 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature