Short- and long-term functional consequences of fluoxetine exposure during adolescence in male rats.

ABSTRACT:

Background

Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is prescribed for the treatment of major depressive disorder in young populations. Here, we explore the short- and long-term consequences of adolescent exposure to FLX on behavioral reactivity to emotion-eliciting stimuli.

Methods

Adolescent male rats received FLX (10 mg/kg) twice daily for 15 consecutive days (postnatal days 35-49). The influence of FLX on behavioral reactivity to rewarding and aversive stimuli was assessed 24 hours (short-term) or 3 weeks after FLX treatment (long-term). A separate group of adult rats was also treated with FLX (postnatal days 65-79) and responsiveness to forced swimming was assessed at identical time intervals as with the adolescents.

Results

Fluoxetine exposure

SUBMITTER: Iniguez SD 

PROVIDER: S-EPMC2868075 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature