Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy.

ABSTRACT:

Background

Immune features of infants with food allergy have not been delineated.

Objectives

We sought to explore the basic mechanisms responsible for food allergy and identify biomarkers, such as skin prick test (SPT) responses, food-specific IgE levels, and mononuclear cell responses, in a cohort of infants with likely milk/egg allergy at increased risk of peanut allergy.

Methods

Infants aged 3 to 15 months were enrolled with a positive SPT response to milk or egg and either a corresponding convincing clinical history of allergy to milk or egg or moderate-to-severe atopic dermatitis. Infants with known peanut allergy were excluded.

Results

Overall, 512 infants (67% male) were studied, with 308 (60%) having a history of a clinical reaction. Skin test responses

SUBMITTER: Sicherer SH 

PROVIDER: S-EPMC2868273 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature