Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study.

ABSTRACT:

Objectives

To identify genes contributing to variation in echocardiographic left ventricular mass and related traits using linkage and linkage disequilibrium analysis in sibships ascertained on hypertension.

Methods

The Hypertension Genetic Epidemiology Network (HyperGEN) Study of left ventricular hypertrophy characterized left ventricular mass, relative wall thickness (RWT), and aortic root diameter (ARD) with echocardiograms collected using a standardized protocol at four HyperGEN field centers. A high-throughput scanning fluorescence detector system genotyped 387 polymorphisms distributed throughout the genome. Linkage analyses were conducted once genotyping results became available for 885 siblings from 382 sibships.

Results

Although single logarithm of the odds (

SUBMITTER: Arnett DK 

PROVIDER: S-EPMC2868312 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature