A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches.

ABSTRACT:

Background

Numerous studies point to a positive relationship between elevated levels of estrogens and increased risk of breast. Androgens are converted to estrogens by the aromatase enzyme, which is encoded by the CYP19 gene. We recently published resequencing data on 88 polymorphisms identified in that gene. The hypothesis tested in this study was that polymorphisms, or haplotypes, in CYP19 are related to risk of breast cancer.

Methods

Incident cases of breast cancer were identified through the Division of Medical Oncology at the Mayo Clinic in Rochester, MN. Controls were patients visiting Mayo for an annual medical examination. Controls were frequency matched to cases based on age and region of residence. Tag-polymorphisms were selected using 2 methods: (1) 12 variants us

SUBMITTER: Olson JE 

PROVIDER: S-EPMC2868324 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature