An ecological correlation study of late age-related macular degeneration and the complement factor H Y402H polymorphism.

ABSTRACT:

Purpose

To investigate whether variation in the distribution of the risk allele frequency of the Y402H single-nucleotide polymorphism (SNP) across various ethnicities and geographic regions reflects differences in the prevalence of late age-related macular degeneration (AMD) in those ethnicities.

Methods

Published data were obtained via a systematic search. Study samples were grouped into clusters by ethnicity and geographic location and the Spearman correlation coefficient of the prevalence of late AMD and risk allele frequencies was calculated across clusters.

Results

Across all ethnicities, AMD prevalence was seen to increase with age. Populations of European descent had both higher risk allele frequencies and prevalence of late AMD than did Japanese, Chinese, and

SUBMITTER: Nonyane BA 

PROVIDER: S-EPMC2868481 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature