Vitamin D levels, lung function, and steroid response in adult asthma.

ABSTRACT:

Rationale

Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma.

Objectives

To determine the effect of vitamin D levels on phenotype and GC response in asthma.

Methods

Nonsmoking adults with asthma were enrolled in a study assessing the relationship between serum 25(OH)D (vitamin D) concentrations and lung function, airway hyperresponsiveness (AHR), and GC response, as measured by dexamethasone-induced expression of mitogen-activated protein kinase phosphatase (MKP)-1 by peripheral blood mononuclear cells.

Measurements and main results

A total of 54 adults with asthma (FEV(1), 82.9 +/- 15.7% predicted [mean +/- SD], serum vitamin D level

SUBMITTER: Sutherland ER 

PROVIDER: S-EPMC2868500 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature