Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1.

ABSTRACT:

Background/aims

Hypothalamic hamartomas are the most common identifiable cause of central precocious puberty (CPP). Hamartoma characteristics proposed to be associated with CPP include specific anatomic features and expression of molecules such as gonadotropin-releasing hormone (GnRH), transforming growth factor alpha (TGFalpha), and GRM1A, which encodes the type 1 metabotropic glutamate receptor alpha isoform. We sought to determine whether hamartomas that cause CPP could be distinguished by anatomic features, expression of these molecules, or expression of KISS1, whose products signal through the receptor GPR54 to stimulate GnRH release.

Methods

Clinical records and radiologic images were reviewed for 18 patients who underwent hamartoma resection for intractable seizures;

SUBMITTER: Chan YM 

PROVIDER: S-EPMC2868525 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature