Metabolic labeling of sialic acids in living animals with alkynyl sugars.

ABSTRACT: Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

SUBMITTER: Chang PV 

PROVIDER: S-EPMC2868584 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature