Adipose tissue pathways involved in weight loss of cancer cachexia.

ABSTRACT:

Background

The regulatory gene pathways that accompany loss of adipose tissue in cancer cachexia are unknown and were explored using pangenomic transcriptome profiling.

Methods

Global gene expression profiles of abdominal subcutaneous adipose tissue were studied in gastrointestinal cancer patients with (n=13) or without (n=14) cachexia.

Results

Cachexia was accompanied by preferential loss of adipose tissue and decreased fat cell volume, but not number. Adipose tissue pathways regulating energy turnover were upregulated, whereas genes in pathways related to cell and tissue structure (cellular adhesion, extracellular matrix and actin cytoskeleton) were downregulated in cachectic patients. Transcriptional response elements for hepatic nuclear factor-4 (HNF4) were overre

SUBMITTER: Dahlman I 

PROVIDER: S-EPMC2869165 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature