Dynamic computational model suggests that cellular citizenship is fundamental for selective tumor apoptosis.

ABSTRACT: Computational models in the field of cancer research have focused primarily on estimates of biological events based on laboratory generated data. We introduce a novel in-silico technology that takes us to the next level of prediction models and facilitates innovative solutions through the mathematical system. The model's building blocks are cells defined phenotypically as normal or tumor, with biological processes translated into equations describing the life protocols of the cells in a quantitative and stochastic manner. The essentials of communication in a society composed of normal and tumor cells are explored to reveal "protocols" for selective tumor eradication. Results consistently identify "citizenship properties" among cells that are essential for the induction of healing processes

SUBMITTER: Olsen M 

PROVIDER: S-EPMC2869358 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature