CRP gene variation and risk of community-acquired pneumonia.

ABSTRACT:

Background and objective

CRP has several potentially antibacterial effects, and variation in the CRP gene is known to influence CRP levels. Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain.

Methods

We evaluated a series of haplotype-tagging single nucleotide polymorphisms among 5374 individuals in the Cardiovascular Health Study, a cohort of older adults from four communities, who were followed for community-acquired pneumonia for 12-13 years. Secondarily, we evaluated whether these polymorphisms varied among men in the Health Professionals Follow-up Study who self-reported pneumonia on biennial questionnaires.

Results

There were 581 (507 white and 74 black) Cardiovascular Health Study parti

SUBMITTER: Mukamal KJ 

PROVIDER: S-EPMC2869386 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature