Family-based analysis of candidate genes for polycystic ovary syndrome.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) is a complex disorder having both genetic and environmental components. A number of association studies based on candidate genes have reported significant association, but few have been replicated. D19S884, a polymorphic marker in fibrillin 3 (FBN3), is one of the few association findings that has been replicated in independent sets of families.

Objective

The aims of the study are: 1) to genotype single nucleotide polymorphisms (SNPs) in the region of D19S884; and 2) to follow up with an independent data set, published results reporting evidence for PCOS candidate gene associations.

Design

The transmission disequilibrium test (TDT) was used to analyze linkage and association between PCOS and SNPs in candidate genes previously r

SUBMITTER: Ewens KG 

PROVIDER: S-EPMC2869537 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature