Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns.

ABSTRACT:

Context

The human growth hormone/chorionic somatomammotropin (hGH/CSH) locus at 17q22-24, consisting of one pituitary-expressed postnatal (GH1) and four placenta-expressed genes (GH2, CSH1, CSH2, and CSHL1), is implicated in regulation of postnatal and intrauterine growth. A positive correlation has been reported between the offspring's birth weight and serum placental GH (coded by GH2) and placental lactogen (coded by CSH1, CSH2) levels in pregnant women.

Objective

The objective of the study was the investigation of the hypothesis that the mRNA expression profile of placental hGH/CSH genes contributes to the determination of birth weight.

Design and subjects

We developed a sensitive, fluorescent-labeled semiquantitative RT-PCR assay coupled with gene-specific restric

SUBMITTER: Mannik J 

PROVIDER: S-EPMC2869554 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature