Reconstruction and validation of RefRec: a global model for the yeast molecular interaction network.

ABSTRACT: Molecular interaction networks establish all cell biological processes. The networks are under intensive research that is facilitated by new high-throughput measurement techniques for the detection, quantification, and characterization of molecules and their physical interactions. For the common model organism yeast Saccharomyces cerevisiae, public databases store a significant part of the accumulated information and, on the way to better understanding of the cellular processes, there is a need to integrate this information into a consistent reconstruction of the molecular interaction network. This work presents and validates RefRec, the most comprehensive molecular interaction network reconstruction currently available for yeast. The reconstruction integrates protein synthesis pathways, a

SUBMITTER: Aho T 

PROVIDER: S-EPMC2871048 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature