Intrinsically disordered proteins in bcl-2 regulated apoptosis.

ABSTRACT: Intrinsic cell death is mediated by interaction between pro-apoptotic and pro-survival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.

SUBMITTER: Rautureau GJ 

PROVIDER: S-EPMC2871139 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature