VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation.

ABSTRACT: Sympathetic nerve activity regulates blood pressure by altering peripheral vascular resistance. Variations in vascular sympathetic innervation suggest that vascular-derived cues promote selective innervation of particular vessels during development. As axons extend towards peripheral targets, they migrate along arterial networks following gradients of guidance cues. Collective ratios of these gradients may determine whether axons grow towards and innervate vessels or continue past non-innervated vessels towards peripheral targets. Utilizing directed neurite outgrowth in a three-dimensional (3D) co-culture, we observed increased axon growth from superior cervical ganglion explants (SCG) towards innervated compared to non-innervated vessels, mediated in part by vascular endothelial growth fa

SUBMITTER: Long JB 

PROVIDER: S-EPMC2871302 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature