Direct determination of molecular haplotypes by chromosome microdissection.

ABSTRACT: Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci.

SUBMITTER: Ma L 

PROVIDER: S-EPMC2871314 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature