Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.

ABSTRACT: The netrin-like (NTR) domain is a feature of several extracellular proteins, most notably the N-terminal domain of tissue inhibitors of metalloproteinases (TIMPs), where it functions as a strong inhibitor of matrix metalloproteinases and some other members of the metzincin superfamily. The presence of a C-terminal NTR domain in procollagen C-proteinase enhancers (PCPEs), proteins that stimulate the activity of astacin-like tolloid proteinases, raises the possibility that this might also have inhibitory activity. Here we show that both long and short forms of the PCPE-1 NTR domain, the latter beginning at the N-terminal cysteine known to be critical for TIMP activity, show no inhibition, at micromolar concentrations, of several members of the metzincin superfamily, including matrix metallop

SUBMITTER: Bekhouche M 

PROVIDER: S-EPMC2871463 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature